Charlotte Scott
PI, University of Ghent
I have been involved in many impactful studies detailing the role of myeloid immune cells. I have demonstrated the role of Zeb2 in pDCs, cDC2s, and tissue macrophages. My work demonstrating that nurture by the local environment rather than the nature of the progenitors defines hepatic macrophage heterogeneity (Nat Comms 2016) led to the proposal of the niche hypothesis (NRI 2017), which is now being investigated by many labs. My independent laboratory focuses on understanding the heterogeneity and functions of myeloid cells in NAFLD. To study this, I was awarded an ERC starting grant in 2019. Through the use of state-of-the-art transcriptomic approaches (crucial for this EOS project), the first publication from my lab identified a novel population of macrophages in the fatty liver (Immunity 2020). Since then, we have also generated a spatially resolved atlas of healthy and obese livers across species (Cell 2022), providing a baseline of the healthy human liver for comparison in this consortium. My lab is also committed to having a societal impact through science communication. We regularly participate in outreach events, including the Biotechdag, Pint of Science, and Sound of Science Festival.
